Our web site is hosted by MaximumASP on a virtual server instance, which has been working out really well for us. We have both our dev/test and production IIS virtual servers running off of this box and it hasn't broken a sweat.

Loggo

Our site is built on Loggo, the pet project of roadie Jason Mauer. It's a content management framework with blog DNA built on ASP.NET. More info on Loggo (and hopefully a source release) coming soon.

TwitterSync

On our server, we're also running an app that hosts Windows Workflow Foundation to do periodic updates of the site. Right now that consists of pulling updates from our Twitter feed and using that to update the status of our Roadies. We run a state machine workflow that checks every so often, but not too often (Twitter shuts down their web services if you hit them too often)... handling this in Windows Workflow is a piece of cake.